CDK5RAP3 antibody - 100 µg
Host : Rabbit
Clonality: Polyclonal
Clone:
Isotype: IgG
Immunogen: CDK5 regulatory subunit associated protein 3
Purity: ≥95% as determined by SDS-PAGE
Form: Liquid
Molecular weight: 65 kDa
Uniprot: Q96JB5
Gene id: 80279
Background: Probable tumor suppressor initially identified as a CDK5R1 interactor controlling cell proliferation(PubMed:12054757, PubMed:12737517). Negatively regulates NF-kappa-B-mediated gene transcription through the control of RELA phosphorylation(PubMed:17785205, PubMed:20228063). Also regulates mitotic G2
M transition checkpoint and mitotic G2 DNA damage checkpoint(PubMed:15790566, PubMed:19223857). Through its interaction with CDKN2A
ARF and MDM2 may induce MDM2-dependent p53
TP53 ubiquitination, stabilization and activation in the nucleus, thereby promoting G1 cell cycle arrest and inhibition of cell proliferation(PubMed:16173922). May play a role in the unfolded protein response, mediating the ufmylation of multiple proteins in response to endoplasmic reticulum stress(PubMed:23152784). May also play a role in the rupture of the nuclear envelope during apoptosis(PubMed:23478299). May regulate MAPK14 activity by regulating its dephosphorylation by PPM1D
WIP1(PubMed:21283629). (Microbial infection) May be negatively regulated by hepatitis B virus large envelope protein mutant pre-s2 to promote mitotic entry.
Field of research: Cell Division and Proliferation
Storage conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze
thaw cycles.)
Applications: ELISA, WB, IHC, IF, FC
Dilution: WB: 1:500-1:2000; IHC: 1:20-1:200; IF: 1:20-1:200
Target: CDK5RAP3
Purification: Immunogen affinity purified
Reactivity: Human, Mouse, Rat
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Clonality: Polyclonal
Clone:
Isotype: IgG
Immunogen: CDK5 regulatory subunit associated protein 3
Purity: ≥95% as determined by SDS-PAGE
Form: Liquid
Molecular weight: 65 kDa
Uniprot: Q96JB5
Gene id: 80279
Background: Probable tumor suppressor initially identified as a CDK5R1 interactor controlling cell proliferation(PubMed:12054757, PubMed:12737517). Negatively regulates NF-kappa-B-mediated gene transcription through the control of RELA phosphorylation(PubMed:17785205, PubMed:20228063). Also regulates mitotic G2
M transition checkpoint and mitotic G2 DNA damage checkpoint(PubMed:15790566, PubMed:19223857). Through its interaction with CDKN2A
ARF and MDM2 may induce MDM2-dependent p53
TP53 ubiquitination, stabilization and activation in the nucleus, thereby promoting G1 cell cycle arrest and inhibition of cell proliferation(PubMed:16173922). May play a role in the unfolded protein response, mediating the ufmylation of multiple proteins in response to endoplasmic reticulum stress(PubMed:23152784). May also play a role in the rupture of the nuclear envelope during apoptosis(PubMed:23478299). May regulate MAPK14 activity by regulating its dephosphorylation by PPM1D
WIP1(PubMed:21283629). (Microbial infection) May be negatively regulated by hepatitis B virus large envelope protein mutant pre-s2 to promote mitotic entry.
Field of research: Cell Division and Proliferation
Storage conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze
thaw cycles.)
Applications: ELISA, WB, IHC, IF, FC
Dilution: WB: 1:500-1:2000; IHC: 1:20-1:200; IF: 1:20-1:200
Target: CDK5RAP3
Purification: Immunogen affinity purified
Reactivity: Human, Mouse, Rat