CDC14B antibody - 100 µg
Host : Rabbit
Clonality: Polyclonal
Clone:
Isotype: IgG
Immunogen: CDC14 cell division cycle 14 homolog B
Purity: ≥95% as determined by SDS-PAGE
Form: Liquid
Molecular weight: 56 kDa
Uniprot: O60729
Gene id: 8555
Background: Dual-specificity phosphatase involved in DNA damage response. Essential regulator of the G2 DNA damage checkpoint: following DNA damage, translocates to the nucleus and dephosphorylates FZR1
CDH1, a key activator of the anaphase promoting complex
cyclosome(APC
C). Dephosphorylates SIRT2 around early anaphase. Dephosphorylation of FZR1
CDH1 activates the APC
C, leading to the ubiquitination of PLK1, preventing entry into mitosis. Preferentially dephosphorylates proteins modified by proline-directed kinases.
Field of research: Cell Division and Proliferation, Metabolism
Storage conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze
thaw cycles.)
Applications: ELISA, WB
Dilution: WB: 1:500-1:2000
Target: CDC14B
Purification: Immunogen affinity purified
Reactivity: Human
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Clonality: Polyclonal
Clone:
Isotype: IgG
Immunogen: CDC14 cell division cycle 14 homolog B
Purity: ≥95% as determined by SDS-PAGE
Form: Liquid
Molecular weight: 56 kDa
Uniprot: O60729
Gene id: 8555
Background: Dual-specificity phosphatase involved in DNA damage response. Essential regulator of the G2 DNA damage checkpoint: following DNA damage, translocates to the nucleus and dephosphorylates FZR1
CDH1, a key activator of the anaphase promoting complex
cyclosome(APC
C). Dephosphorylates SIRT2 around early anaphase. Dephosphorylation of FZR1
CDH1 activates the APC
C, leading to the ubiquitination of PLK1, preventing entry into mitosis. Preferentially dephosphorylates proteins modified by proline-directed kinases.
Field of research: Cell Division and Proliferation, Metabolism
Storage conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze
thaw cycles.)
Applications: ELISA, WB
Dilution: WB: 1:500-1:2000
Target: CDC14B
Purification: Immunogen affinity purified
Reactivity: Human