CBFA2T2 antibody - 100 µg
Host : Rabbit
Clonality: Polyclonal
Clone:
Isotype: IgG
Immunogen: core-binding factor, runt domain, alpha subunit 2; translocated to, 2
Purity: ≥95% as determined by SDS-PAGE
Form: Liquid
Molecular weight: 85 kDa
Uniprot: O43439
Gene id: 9139
Background: Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes(PubMed:12559562, PubMed:15203199). Via association with PRDM14 is involved in regulation of embryonic stem cell(ESC) pluripotency(PubMed:27281218). Involved in primordial germ cell(PCG) formation. Stabilizes PRDM14 and OCT4 on chromatin in a homooligomerization-dependent manner(By similarity). Can repress the expression of MMP7 in a ZBTB33-dependent manner(PubMed:23251453). May function as a complex with the chimeric protein RUNX1
AML1-CBFA2T1
MTG8(AML1-MTG8
ETO fusion protein) which is produced in acute myeloid leukemia with the chromosomal translocation t(8;21). May thus be involved in the repression of AML1-dependent transcription and the induction of G-CSF
CSF3-dependent cell growth. May be a tumor suppressor gene candidate involved in myeloid tumors with the deletion of the 20q11 region. Through heteromerization with CBFA2T3
MTG16 may be involved in regulation of the proliferation and the differentiation of erythroid progenitors by repressing the expression of TAL1 target genes(By similarity). Required for the maintenance of the secretory cell lineage in the small intestine. Can inhibit Notch signaling probably by association with RBPJ and may be involved in GFI1-mediated Paneth cell differentiation(By similarity).
Field of research: Metabolism
Storage conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze
thaw cycles.)
Applications: ELISA, WB, IHC
Dilution: WB: 1:500-1:2000; IHC: 1:20-1:200
Target: CBFA2T2
Purification: Immunogen affinity purified
Reactivity: Human, Mouse, Rat
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Clonality: Polyclonal
Clone:
Isotype: IgG
Immunogen: core-binding factor, runt domain, alpha subunit 2; translocated to, 2
Purity: ≥95% as determined by SDS-PAGE
Form: Liquid
Molecular weight: 85 kDa
Uniprot: O43439
Gene id: 9139
Background: Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes(PubMed:12559562, PubMed:15203199). Via association with PRDM14 is involved in regulation of embryonic stem cell(ESC) pluripotency(PubMed:27281218). Involved in primordial germ cell(PCG) formation. Stabilizes PRDM14 and OCT4 on chromatin in a homooligomerization-dependent manner(By similarity). Can repress the expression of MMP7 in a ZBTB33-dependent manner(PubMed:23251453). May function as a complex with the chimeric protein RUNX1
AML1-CBFA2T1
MTG8(AML1-MTG8
ETO fusion protein) which is produced in acute myeloid leukemia with the chromosomal translocation t(8;21). May thus be involved in the repression of AML1-dependent transcription and the induction of G-CSF
CSF3-dependent cell growth. May be a tumor suppressor gene candidate involved in myeloid tumors with the deletion of the 20q11 region. Through heteromerization with CBFA2T3
MTG16 may be involved in regulation of the proliferation and the differentiation of erythroid progenitors by repressing the expression of TAL1 target genes(By similarity). Required for the maintenance of the secretory cell lineage in the small intestine. Can inhibit Notch signaling probably by association with RBPJ and may be involved in GFI1-mediated Paneth cell differentiation(By similarity).
Field of research: Metabolism
Storage conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze
thaw cycles.)
Applications: ELISA, WB, IHC
Dilution: WB: 1:500-1:2000; IHC: 1:20-1:200
Target: CBFA2T2
Purification: Immunogen affinity purified
Reactivity: Human, Mouse, Rat