BHLHE41 antibody - 100 µg
Host : Rabbit
Clonality: Polyclonal
Clone:
Isotype: IgG
Immunogen: basic helix-loop-helix family, member e41
Purity: ≥95% as determined by SDS-PAGE
Form: Liquid
Molecular weight: 51 kDa, 75 kDa
Uniprot: Q9C0J9
Gene id: 79365
Background: Transcriptional repressor involved in the regulation of the circadian rhythm by negatively regulating the activity of the clock genes and clock-controlled genes. Acts as the negative limb of a novel autoregulatory feedback loop(DEC loop) which differs from the one formed by the PER and CRY transcriptional repressors(PER
CRY loop). Both these loops are interlocked as it represses the expression of PER1 and in turn is repressed by PER1
2 and CRY1
2. Represses the activity of the circadian transcriptional activator: CLOCK-ARNTL
BMAL1 heterodimer by competing for the binding to E-box elements(5'-CACGTG-3') found within the promoters of its target genes. Negatively regulates its own expression and the expression of DBP and BHLHE41
DEC2. Acts as a corepressor of RXR and the RXR-LXR heterodimers and represses the ligand-induced RXRA
B
G, NR1H3
LXRA, NR1H4 and VDR transactivation activity.
Field of research: Neuroscience, Epigenetics, Metabolism, Developmental biology
Storage conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze
thaw cycles.)
Applications: ELISA, WB
Dilution: WB: 1:1000-1:2000
Target: BHLHE41
Purification: Immunogen affinity purified
Reactivity: Human, Mouse, Rat
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Clonality: Polyclonal
Clone:
Isotype: IgG
Immunogen: basic helix-loop-helix family, member e41
Purity: ≥95% as determined by SDS-PAGE
Form: Liquid
Molecular weight: 51 kDa, 75 kDa
Uniprot: Q9C0J9
Gene id: 79365
Background: Transcriptional repressor involved in the regulation of the circadian rhythm by negatively regulating the activity of the clock genes and clock-controlled genes. Acts as the negative limb of a novel autoregulatory feedback loop(DEC loop) which differs from the one formed by the PER and CRY transcriptional repressors(PER
CRY loop). Both these loops are interlocked as it represses the expression of PER1 and in turn is repressed by PER1
2 and CRY1
2. Represses the activity of the circadian transcriptional activator: CLOCK-ARNTL
BMAL1 heterodimer by competing for the binding to E-box elements(5'-CACGTG-3') found within the promoters of its target genes. Negatively regulates its own expression and the expression of DBP and BHLHE41
DEC2. Acts as a corepressor of RXR and the RXR-LXR heterodimers and represses the ligand-induced RXRA
B
G, NR1H3
LXRA, NR1H4 and VDR transactivation activity.
Field of research: Neuroscience, Epigenetics, Metabolism, Developmental biology
Storage conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze
thaw cycles.)
Applications: ELISA, WB
Dilution: WB: 1:1000-1:2000
Target: BHLHE41
Purification: Immunogen affinity purified
Reactivity: Human, Mouse, Rat